![]() Įstradiol valerate by intramuscular injection is usually used at a dosage of 10 to 20 mg every 4 weeks in the treatment of menopausal symptoms and hypoestrogenism due to hypogonadism, castration, or primary ovarian failure in women. Such symptoms may include hot flashes, outbreaks of sweat, sleep disturbances, depressive moods, irritability, headaches, and dizziness. Elsewhere in the world, oral estradiol valerate is similarly approved for the treatment of symptoms associated with menopause or hypoestrogenism due to castration in women. In the United States, the approved indications of estradiol valerate injections include the treatment of moderate to severe hot flashes and vaginal atrophy associated with menopause in women, the treatment of hypoestrogenism due to hypogonadism, castration, or primary ovarian failure in women, and the palliative treatment of advanced prostate cancer in men. Injectable estradiol valerate has been used to suppress sex drive in sex offenders. Low-dose oral estradiol valerate (2–6 mg/day) has been used in the treatment of breast cancer in women who were previously treated with and benefited from but acquired resistance to aromatase inhibitors as well. It is also used as a form of high-dose estrogen therapy in the treatment of prostate cancer in men. Along with estradiol cypionate, estradiol undecylate, and estradiol benzoate, estradiol valerate is used as a form of high-dose estrogen therapy in feminizing hormone therapy for transgender women. In regard to the latter, estradiol valerate is available in combination with a progestin as a combined estradiol-containing oral contraceptive (with dienogest) and as a combined injectable contraceptive. Examples of indications for the medication include hormone therapy and hormonal contraception. The medical uses of estradiol valerate are the same as those of estradiol and other estrogens. See also: Estradiol (medication) § Medical uses Estradiol valerate is used in the United States, Canada, Europe, and throughout much of the rest of the world. Along with estradiol cypionate, it is one of the most widely used esters of estradiol. Įstradiol valerate was first described in 1940 and was introduced for medical use in 1954. ![]() Because of this, it is considered to be a natural and bioidentical form of estrogen. It is an estrogen ester and a prodrug of estradiol in the body. Estradiol valerate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. ![]() Side effects of estradiol valerate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. The medication is taken by mouth or by injection into muscle or fat once every 1 to 4 weeks. It is also used in the treatment of prostate cancer in men. In women, it is used in hormone therapy for menopausal symptoms and low estrogen levels, hormone therapy for transgender people, and in hormonal birth control. Custom configurations – skid mounted heat exchangers, control valves, instrumentation, etc.Estradiol valerate ( EV), sold for use by mouth under the brand name Progynova and Primiwal E4 and for use by injection under the brand names Delestrogen and Progynon Depot among others, is an estrogen medication.Advanced control system options – Sigma Automation.Integrated control system with required safety interlocks and modulating controls.With or without mounted and pre-piped expansion tank.Skid mounted with control panel and primary circulation pump.Pre-engineered designs are available for quick procurement.Compliance with latest NFPA 87 requirements.If you have questions, contact an application engineer today. If you already understand your needs, you can submit an RFQ here. Sigma Thermal offers standard SHOTS configurations from 30kW to 800kW, and custom configurations from 800kW to 4MW or higher. By using an electric circulation heater and a low watt density immersion bundle we create a simple, robust, and reliable system that allows for use of electricity instead of natural gas, fuel oil, or biomass fuel sources. Sigma Hot Oil Transfer System (SHOTS) are electrically powered thermal fluid heating systems. ![]()
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